In Destroy Mode, the Unicorn Gundam's psycho-frame scans the pilot's thoughts and directly transmits them to the suit's drive system; in other words, the Unicorn can be controlled by thoughts alone. Additionally, the mode also causes the machine's performance - in thrust, generator output, and sensory radius - to be increased to unmeasurable levels. The NT-D also allows the Unicorn to take control of an enemy's psycommu weapons by emitting a Psycho-Field. However, the stress placed on the mind by manipulating an object more than tenfold the size of an average human is extraordinary. Even with the aid of the psycho-frame, the pilot's mind can only endure roughly five minutes of operation before a limiter is activated, deactivating the psycho-frame and returning the mobile suit to its Unicorn Mode.

With the performance limiters disengaged, the Unicorn can accelerate up to 20 G's in Destroy Mode; to alleviate such high levels of G forces placed on the pilot, a drug administration system called the "DDS" is fitted on the pilot suit. It suppresses stagnated blood circulation due to high acceleration by administering the drug to the pilot.