Anaheim Electronics constructed one ZII unit before the design team was requested to place priority on the MSZ-010 ΖΖ Gundam for the A.E.U.G.. The ZII was assigned to former A.E.U.G. Assault Squadron Commander Kei Kirishima during the events of the First Neo Zeon War to capture the asteroid base Axis. After the war, the unit was put into storage by Anaheim and its concept was subsequently used as the basis for the development of the RGZ-95 ReZEL.
In U.C. 0090, Earth Federation Forces pilot Travis Kirkland acquired the ZII from Anaheim and painted it in similar colors used by the RX-79[G]SW Slave Wraith. Piloting the ZII, Travis went searching for his son, Vincent Gleissner, before encountering remnants of the Glemy Faction.
A modified ZII with a visor in the vein of the MSZ-010A1 Theta Plus instead of the twin-eye camera and more weapons, including an added shield and a modified Mega Beam Rifle, was seen alongside the Federation forces at Olympus in Mobile Suit Gundam Walpurgis. It fought against the AGX-11 Over.on and tried to ram it, but the attack failed. It later retreated when the AMX-114 Demeter lured and engaged the Over.on outside the colony.