The suit's backpack is equipped with three weapons, including two twin barrel high-energy beam cannons, 20 thermal plasma composite cannons mounted around the backpack's circumference, and four 6-tube multipurpose missile launchers. Other weapons include head-mounted 200mm energy cannon and four 75mm CIWS, three chest-mounted 1580mm multi-phase energy cannons, and two detachable arms each equipped with a beam cannon and 5-barrel hand beam gun. The detachable arms function like DRAGOON Pods, allowing the suit to attack its target at any range, regardless of obstacles standing in the way. Aside from its vast array of offensive weaponry, the Destroy Gundam also carries defensive equipment in the form of three positron reflector shields, one in the backpack and usable only in MA mode, and two on the detachable arms.

Due to its bulk, the Destroy Gundam has poor mobility and serves more as a movable gun platform. This weakness is often exploited by enemy units, particularly high mobility mobile suits piloted by ace pilots, to take the Destroy Gundam down by closing in and using close combat beam weaponry.